Publications

Leonard, J.D., Gilmore, D.C., Dileepan, T., Nawrocka, W.I., Chao, J.L., Schoenbach, M.H., Jenkins, M.K., Adams, E.J., and Savage, P.A. (2017).  Identification of natural regulatory T cell epitopes reveals convergence on a dominant autoantigen.  Immunity, In Press, http//dx.doi.org/10.1016/j.immuni.2017.06.015.

Malchow, S., Leventhal, D.S., Lee, V., Nishi, S., Socci, N.D., and Savage, P.A. (2016).  Aire enforces immune tolerance by directing autoreactive T cells into the regulatory T cell lineage.  Immunity, 44, 1102-1113.

Leventhal, D.S., Gilmore, D.C., Berger, J., Nishi, S., Malchow, S., Kline, D.E., Kline, J., Vander Griend, D.J., Huang, H., Socci, N.D., and Savage, P.A. (2016).  Dendritic cells coordinate the development and homeostasis of organ-specific regulatory T cells.  Immunity 44, 847-859.

Lee, V., and Savage, P.A. (2015).  Close encounters of the tertiary kind.  Immunity 43, 418-420.

Kreymborg, K., Haak, S., Murali, R., Wei, J., Waitz, R., Gasteiger, G., Savage, P.A., van den Brink, M.R., and Allison, J.P. (2015).  Ablation of B7-H3 but not B7-H4 results in highly increased tumor burden in a murine model of spontaneous prostate cancer.  Cancer Immunology Research 3:849-854.

Chen, X., Fosco, D., Kline, D.E., Meng, L., Nishi, S., Savage, P.A., and Kline, J. (2014).  PD-1 regulates extrathymic regulatory T-cell differentiation.  European Journal of Immunology, 44: 2603–2616.

Nalle, S.C., Kwak, A., Edelblum, K.L., Joseph, N.E., Singh, G., Khramtsova, G.F., Mortenson, E.D., Savage, P.A.*, and Turner, J.R.* (2014).  Recipient NK cell inactivation and intestinal barrier loss are required for MHC-matched graft-versus-host disease.  Science Translational Medicine, 6:243ra87.  * Denotes co-corresponding authors.

Savage, P.A. (2014).  Tumor antigenicity revealed.  Trends in Immunology 35, 47-48.

Savage, P.A., Malchow, S., and Leventhal, D.S. (2013).  Organ-specific regulatory T cells of thymic origin are expanded in murine prostate tumors.  OncoImmunology 2:e24898.

Malchow, S., Leventhal, D.S., Nishi, S., Fischer, B.I., Shen, L., Paner, G.P., Amit, A.S., Kang, C., Geddes, J.E., Allison, J.P., Socci, N.D., and Savage, P.A. (2013).  Aire-dependent thymic development of tumor-associated regulatory T cells.  Science, 339, 1219-1224.
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Savage, P.A., Malchow, S., Leventhal, D.S. (2013).  Basic principles of tumor-associated regulatory T cells. Trends In Immunology, 34. 33-40.

Donkor, M.K., Sarkar, A., Savage, P.A., Franklin, R.A., Johnson, L.K., Jungbluth, A.A., Allison, J.P., and Li, M.O. (2011).  Cell-autonomous TGF-b signaling suppresses T cell surveillance of tumor development.  Immunity 35, 123-134.

Savage, P.A., Vosseller, K., Kang, C., Larimore, K., Riedel, E., Wojnoonski, K., Jungbluth, A.A., and Allison, J.P. (2008).  Recognition of a ubiquitous self antigen by prostate cancer-infiltrating CD8⁺ T lymphocytes.  Science 319, 215-220.

Savage, P.A. and Davis, M.M. (2001).  A kinetic window constricts the T cell receptor repertoire in the thymus.  Immunity 14, 243-252.

Lee, P.P., Yee, C., Savage, P.A., Fong, L., Brockstedt, D., Weber, J.S., Johnson, D., Swetter, S., Thompson, J., Greenberg, P.D., Roederer, M., and Davis, M.M. (1999).  Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients.  Nature Medicine 5, 677-685.

Savage, P.A., Boniface, J.J., and Davis, M.M. (1999).  A kinetic basis for T cell receptor repertoire selection during an immune response.  Immunity 10, 485-492.

Yee, C.,  Savage, P.A., Lee, P.P., Davis, M.M., and Greenberg, P.D. (1999).  Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers.  Journal of Immunology 162, 2227-2234.